First look: Notre Dame at Louisville odds and lines

The No. 11 Notre Dame Fighting Irish (5-1) take on the No. 25 Louisville Cardinals (5-0) in Louisville on Saturday at 7:30 p.m. (ABC). Below, we analyze FanDuel Sportsbook's lines around the Notre Dame vs. Louisville odds, and make our expert college football picks and predictions.

Notre Dame is coming off a defensive struggle against Duke on Saturday. Entering the game as 4.5-point favorites, Notre Dame pulled out a last minute 21-14 win to cover.

Louisville had its toughest game to date last Friday scratching out a 13-10 road win as 3-point favorites against NC State. Notre Dame will be coach Jeff Brohm's biggest test to keep the Cardinals undefeated.

Notre Dame is No. 11 and Louisville No. 25 in the US LBM Coaches Poll powered by USA TODAY Sports.

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Notre Dame at Louisville odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:25 a.m. ET.

• Moneyline(ML): Notre Dame -260 (bet $260 to win $100) | Louisville +210 (bet $100 to win $210)
• Against the spread (ATS): Notre Dame -7 (-105) | Louisville +7 (-115)
• Over/Under (O/U): 51.5 (O: -110 | U: -110)

2023 betting stats

• ML: Notre Dame 5-1 | Louisville 5-0
• ATS: Notre Dame 5-1 | Louisville 2-2-1
• O/U: Notre Dame 3-3 | Louisville 2-2-1

Notre Dame vs. Louisville head-to-head

These teams have only played 3 times in their history and in all 3 games the favorite has failed to cover while the Over has hit once.

The last meeting between the schools was in 2020 at Notre Dame when the Irish came in as 15-point favorites and won 12-7.

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